Endocrine Abstracts

Introduction: In humans, testosterone treatment affects body fat distribution and metabolism. The mechanisms involved in these processes are not yet fully understood. We investigated whether sex hormones modulate the expression and activity of type1 11-β-hydroxy-steroid-dehydrogenase (11β-HSD1). 11β-HSD1 catalyses the conversion of inactive cortisone into active cortisol, a key step for the development of functional adipocytes. Based on previous studies an inhib...

Cannabinoids and ghrelin exert hypothalamic orexigenic effects and independent peripheral effects have also been reported. We have recently reported that ghrelin and cannabinoids can stimulate hypothalamic and heart AMPK activity, and can inhibit liver and adipose tissue AMPK activity, in rats (Kola et al., JBC, 2005). These data are concordant with the known orexigenic, adipogenic and diabetogenic effects of these compounds as well as with their beneficial effects on t...

Introduction: Hypoparathyroidism is the only endocrine deficiency for which replacement therapy with the missing hormone is not part of the clinical practice. High quality evidence on the use of PTH 1-34 or PTH 1-84 in hypoparathyroidism is missing.Objective: We aim to evaluate the efficacy and safety of PTH 1-34 and PTH 1-84, and to compare the two treatments when possible.Methods: We searched databases up to March 2021 for random...

Background: Burned-out tumours (BOT) are rare clinical entities which present with no primary testicular lesion but distant metastases. We report a difficult management of BOT.Case Presentation: A 22-year-old male presented to ER with acute low back pain, severe vomiting and sweating. In past medical history: bilateral orchidopexy for cryptorchidism. Abdominal CT scan displayed two retroperitoneal masses of 35 and 20 mm. The patient was discharged with s...

Introduction: Patients with Klinefelter Syndrome (KS) often display small, multiple, non-palpable, and typically benign testicular micro-nodules at ultrasonographic examination, representing Leydig cell hyperplasia or Leydig tumors. Increased LH levels raising from testicular damage might play a pivotal role by acting as growth factor for Leydig cells. To date, evidence on the efficacy of testosterone replacement therapy (TRT) on decreasing the micro-nodules volume are lacking...

Background: Patients with adrenal insufficiency (AI) require long-term glucocorticoid (GC) replacement therapy and generally show an increased prevalence of bone metabolism alterations. Only few data are available on bone safety of dual-release Hydrocortisone (DR-HC) therapy. Objective: To evaluate bone metabolism in primary AI (PAI) and secondary AI (SAI) during long-term therapy with DR-HC.Methods: We evaluated patients with AI o...

Background: Graves’ orbitopathy (GO) is the major extrathyroidal manifestation of Graves’ disease (GD). Even if usually mild and non-progressive, in its worst forms, GO can represent a major therapeutic challenge, because is not always responsive to the available medical treatments. First line treatment for moderate-to-severe and active GO relies on intravenous (i.v.) methylprednisolone. Optic neuropathy is a sight-threatening complication which can seriously impact ...

Objective: 2–3% of the population of the UK receive glucocorticoid (GC) therapy. Significant adverse effects are not confined to chronic use: recurrent short-course administration is associated with increased morbidity and mortality. Data about the cumulative dose responsible for drawbacks during GC treatment are still lacking. The aim of this study was to test the impact of 7 days of 10 or 15 mg of Prednisolone on metabolism in healthy male volunteers.<p class="abste...

Objective: Currently, 2–3% of the population of the UK and US receive glucocorticoid (GC) therapy. Significant adverse effects are not confined to chronic use; recurrent short-course administration is associated with increased morbidity and mortality. The efficacy of GC therapy is not in doubt but data about the cumulative dose responsible for adverse effects during GC treatment are still lacking. The aim of this study was to test the impact of 7 days of 10 or 15 mg of Pr...

Introduction: GEP-NENs represent a heterogeneous group of neoplasms with increasing incidence in the last years. Pathogenesis and risk factors of sporadic GEP-NENs are not clear and still debated. The aim of this study is to evaluate the main risk factors for sporadic GEP-NENs in patients followed by the NETTARE Unit (NeuroEndocrine TAsk force of of ‘Sapienza’ University of Rome).Methods: We performed a case-control study including 32 consecuti...